chemotherapy in treatment of esophageal
The incidence of esophageal cancerincidence rate of malignant tumor in the world for sixth ,its incidence has obvious regional .In some areas of our country ,esophageal cancer in the morbidity and mortality of malignant tumor in the first place, o Swiss replica watchesur country as esophageal cancer high incidence area has attracted attention from all over the world .
In recent years ,although the tumor therapy have made a lot of progress, but the prognosis of esophageal cancer is still poor ,and overall 5 year survival rate in 10%~20% .50% of patients had distant metastases ;and even if clinically thought to locally advanced esophageal carcinoma confirmed by autopsy ,also has more than 50% cases with distant metastases ,70% with lymph node metastasis .
Thus ,esophageal cancer is a local disease ,is a systemic disease .Conventional treatment to esophageal cancer operation and radiotherapy ,b Cheap wedding dressut the effect is not ideal .Foreign retrospective survey report radio Cheap prom dressestherapy or operation in the treatment of esophageal carcinoma and 5 year survival rates wer Rolex replicae 6% and 11% ;China Professor Wong Kok Ghan reported that simple operation treatment of 1373 cases of esophageal cancer ,5 year survival rate was 29.
6% ,rec Cheap wedding gownsurrence or / and transfer is affected in patients with long term survival in primary cause .Therefore ,to find effective d Replica breitling watchesrugs to contr rolex Fake watchesol esophageal disseminated and explore the comprehensive therapy is the treatment of this deadly disease key .
This article reviews esophagea Rolex replicasl cancer chemotherapeutic agents in the treatment of the newest progress of the comprehensive therapy for esophageal cancer ,in order to provide new ideas and new methods .
1 conventional chemotherapy drug monotherapy in the treatment of esophageal cancer treated with combination chemotherapy provides the basis for .The 60 s esophageal cancer chemotherapy with Cheap wedding dresses single drug ,commonly used drugs bleomycin ( BLM ) ,Mitomycin ( MMC ) ,5- fluorouracil ( 5-FU ) ,adriamycin ( ADM ) ,ammonia armor plate of tetrahydrobiopterin ( MTX ) Replica watch ,etoposide ( VP-16 ) ,effective in 15% so ,without a complete remission Replica rolex of the report .
Because of the potential pulmonary toxicity ,foreign BLM has not used for esophageal cancer in combination with chemotherapy ;MMC also because cumulative bone marrow toxicity has been rarely used ,esophageal carcinoma with combined chemotherapy ,more to substitute 5-FU .
In 80, cisplatin ( DDP ) began to be used in treatment of esophageal cancer, a total of 7 reported single-agent DDP in treatment of esophageal carcinoma .The 6 report of single-agent cisplatin 50~120 mg/m2 ,every 3~4 weeks for a cycle in the treatment of esophageal carcinoma, the total efficiency of 21% .Replica watchesr>Another 1 reported cisplatin 120mg/m2 repeated every 2 weeks ( D1 ,D15 ) in treatment Replica watches of 15 patients with preoperative chemotherapy patients ,with an efficiency of 73% .Less than 5% efficient chemotherapy with ifosfamide ,carboplatin ( IFO ) .
Phase II clinical study showed carboplatin and Changchun spent alkali treatment for esophageal carcinoma in 16 cases ,no 1 patients in remission .Therefore ,in esophageal cancer chemotherapy is not recommended to carboplatin instead of DDP .
Alkaloid medicine of Changchun flower alkali ( NVB ) ,role of microtubules in ,inhibition of microtubule equipment .According to EORTC for initial chemotherapy in patients with esophageal cancer ,with an efficiency of 20% ;and DDP joint ,with an efficiency of 32% .
Esophageal cancer is the most commonly used combination chemotherapy regimens are DDP and 5- FU, have efficiency 25%~35% .Only one report randomized comparison of DDP and DDP with continuous intravenous infusion of 5-FU combined ,for phase II clinical study ,a total of 92 Replica louboutin cases, single agent cisplatin is 18% ,DDP+5-FU is 36% ,two groups had no significant difference in DDP+5-FU group ;but more toxic ,cytotoxic chemotherapy related mortality was 16% ,while the single agent cisplatin no treatment related deaths .
Another phase III clinical reported randomized contrast DDP+5-FU ( CF ) ,FAMTX ( ADM+MTX+5-FU ) and ELF ( Replica Christian louboutin shoes VP-16+CF+5-FU ) in treatment of esophageal carcinoma - ,efficient 10%~20% ,median survival less than 8 months .
It has been proposed by 5-FU does not increase the efficacy of DDP .Visible on conventional chemotherapy drug efficacy is not ideal ,nee christian louboutin replica pumpsd to evaluate new drugs in esophageal carcinoma .2 taxane drug taxane medicine action target point is the inhibition of microtubule depolymerization of microtubules .
Ajani first reported single-agent paclitaxel ( PTX ) 250 mg/m2 every 3 weeks fo wedding gownsr 1 24 hours of continuous intravenous drip ,50 cases with advanced esophageal cancer ,with an efficiency of 32% ,the median remission d Duplicate watches for saleuration of 17 weeks .
PTX containing combined with chemotherapy in treatment of esophageal cancer has achiev Replica Breitlinged further encouraging efficacy .Van der Gaast reported PTX 100~160mg/m2 combined with DDP60mg/m2 phase I clinical therapy for advanced esophageal cancer ,biweekly for a period ,a total of 31 cases, with an efficiency of 55% ,well t Replica Christian louboutinolerated .
Ilson reported that PTX175mg/m23 D1 infusion combined with DDP hours 20mg/m2d1-5 and 5- Christian louboutin replicaFU1g/m2 D1-5 continuous intravenous drip ,21 days for the 1 cycle of treatment ,61 cases of esophageal cancer ,with an efficiency of 48% ,the median time to progression was 5.
7 months ,the median survival time was 10.8 months Fake rolex,but the adverse reactions of heavy ,46% patients required reduction chemotherapy .Chinese Academy of Medical Sciences tumour hospital for treatment of 30 cases of advanced esophageal cancer patients ,PTX 175mg/m2 D1 and DDP 40mg/m2 D2 ,D3 ,21 days for the 1 cycle ,efficiency is 57.
1% ,which completely relieved in 5 cases ( 17.9%) ,partial remission in 11 cases ( 39.3%) .Visible three drug efficacy is not higher than the two joint - PTX+ DDP ,increased 5-FU only increased toxicity .
The United States Eastern Cooperative Oncology Group ( ECOG ) reported Taxotere 3 weeks for 1 cycles of treatment ,including 8 cases of patients with esophageal carcinoma of 2 patients in remission, with an efficiency of 25% .
3 of irinotecan (CPT-11 ) CPT-11 topoisomerase II inhibitors .Recently used treatment of esophageal cancer in .